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The American Diabetes Association (ADA) and European Society of Cardiology (ESC) have increasingly emphasized the need to evaluate therapies for their impact on cardiovascular outcomes

Before you start, think through whether you're prepared for a multi-year or indefinite commitment

The Phase 2 trial indicated that retatrutide is similar in terms of safety and side effects to tirzepatide and semaglutide, and the TRIUMPH-1 Phase 3 trial confirmed a manageable safety profile at all doses tested

This is especially important considering the increasing use of these medications. The authors write that, to their knowledge, this is the first case detailing a patient developing this serious condition after starting tirzepatide for diabetes (in contrast to those treated with tirzepatide for weight loss)